Pharmaceutical Organic Chemistry 2 Notes | B Pharmacy 3rd Semester Noteskarts Notes

Introduction

Pharmaceutical Organic Chemistry 2 Notes | B Pharmacy 3rd Semester Noteskarts Notes The course covers a variety of topics, including:

Unit-1: Benzene and its derivatives:

  • Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
  • Reactions of benzene – nitration, sulphonation, halogenationreactivity, Friedelcrafts alkylation reactivity, limitations, Friedelcrafts acylation.
  • Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction
  • Structure and uses of DDT, Saccharin, BHC and Chloramine

Unit-2: Phenol, Aromatic Amines, Aromatic Acids:

  • Phenol* – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
  • Aromatic Amines* – Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts
  • Aromatic Acids* – Acidity, effect of substituents on acidity and important reactions of benzoic acid.

Unit-3: Fats and Oils:

  • Fatty acids – reactions. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
  • Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.

Unit-4: Polynuclear hydrocarbons:

  • Synthesis, reactions
  • Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

Unit-5: Cyclo alkanes:

  • Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only

 

 

Syllabus

Unit-1: Benzene and its derivatives:

Unit-2: Phenol, Aromatic Amines, Aromatic Acids:

Unit-3: Fats and Oils:

Unit-4: Polynuclear hydrocarbons:

Unit-5: Cyclo alkanes:

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